| Assignment | Title/Topic Question |
| PICO 1 | In children under age 3 with autism spectrum disorder, does Early Start Denver Model (ESDM) compared with the Early Intensive Behavioral Intervention (EIBI) result in greater improvement in cognitive, language, and adaptive functioning outcomes? |
| PICO 2 | In pediatric patients with ACL tears, how does immediate surgical intervention compare to delayed surgical intervention in regards to knee function, stability, re-injury rates, and return to sport? |
| PICO 3 | In pediatric patients with molluscum contagiosum, does active treatment compared with placebo or observation improve lesion clearance, prevention of lesion spread, and treatment-related adverse effects? |
| PICO 4 | In adults with uncomplicated appendicitis, does surgical appendectomy compared to antibiotic therapy result in better clinical outcomes, including treatment success, complications, and patient-reported function? |
| PICO 5 | In adult patients with acute cholecystitis who are high-risk surgical candidates due to advanced age and comorbidities, how does percutaneous cholecystostomy tube placement compared to early laparoscopic cholecystectomy or medical management lead to improved outcomes (complication rates, mortality, resolution of infection, hospital length of stay)? |
| PICO 6 | In women 18 years or older with stage I–II invasive breast cancer, does breast-conserving surgery with sentinel lymph node biopsy and adjuvant radiation compared to mastectomy (with or without reconstruction) result in differences in overall survival, recurrence, and patient-reported quality of life over long-term follow-up? |
| Draft Mini-CAT | |
| Final Mini-Cat |
