| Assignment | Title/Topic Question |
| PICO 1 | In patients with persistent De Quervain’s tenosynovitis symptoms, does surgical intervention compared to conservative management such as splinting, NSAIDs, corticosteroid injections, and physical therapy result in improved pain relief and functional outcomes? |
| PICO 2 | In adults with type 2 diabetes mellitus, do GLP-1 receptor agonists compared with other antihyperglycemic drug classes improve glycemic control (HbA1c reduction) and promote weight loss? |
| PICO 3 | In adults who smoke, does varenicline compared with nicotine replacement therapy result in higher smoking cessation rates? |
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